CSNK2B
Gene Information
- Official Symbol: CSNK2B
- Official Name: casein kinase 2 beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 1460
- UniProt: P67870
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. {ECO:0000250, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.
Pfam Domains GO Terms
Pfam Domains
| CK II beta |
GO Terms
| protein kinase CK2 complex |
| adiponectin-activated signaling pathway |
| positive regulation of activin receptor signaling pathway |
| protein kinase regulator activity |
| morphogenesis of an endothelium |
| endothelial tube morphogenesis |
| regulation of activin receptor signaling pathway |
| PcG protein complex |
| liver regeneration |
| ribonucleoprotein complex binding |
| negative regulation of blood vessel endothelial cell migration |
| phosphatidylcholine biosynthetic process |
| response to testosterone |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of endothelial cell migration |
| regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of epithelial cell migration |
| animal organ regeneration |
| phosphatidylcholine metabolic process |
| peptidyl-threonine phosphorylation |
| regulation of blood vessel endothelial cell migration |
| peptidyl-threonine modification |
| endothelium development |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| nuclear matrix |
| chromatin |
| secretory granule lumen |
| ficolin-1-rich granule lumen |
| liver development |
| regulation of DNA binding |
| hepaticobiliary system development |
| regeneration |
| regulation of endothelial cell migration |
| macroautophagy |
| hormone-mediated signaling pathway |
| regulation of signal transduction by p53 class mediator |
| ammonium ion metabolic process |
| response to ketone |
| cilium |
| glycerophospholipid biosynthetic process |
| regulation of epithelial cell migration |
| glycerolipid biosynthetic process |
| protein folding |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| protein domain specific binding |
| phospholipid biosynthetic process |
| negative regulation of cell migration |
| process utilizing autophagic mechanism |
| autophagy |
| negative regulation of cell motility |
| epithelial tube morphogenesis |
| glycerophospholipid metabolic process |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| transcription factor binding |
| signaling receptor binding |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| protein serine/threonine kinase activity |
| phospholipid metabolic process |
| regulation of binding |
| glycerolipid metabolic process |
| chromatin binding |
| gland development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| morphogenesis of an epithelium |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| organophosphate biosynthetic process |
| tissue morphogenesis |
| lipid biosynthetic process |
| myeloid leukocyte activation |
| cellular response to hormone stimulus |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| tube morphogenesis |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| regulation of protein kinase activity |
| cellular protein-containing complex assembly |
| tube development |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| organophosphate metabolic process |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| leukocyte activation |
| cellular lipid metabolic process |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| export from cell |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| immune effector process |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| phosphorylation |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RNMT | 0.621 |
| GFPT1 | 0.616 |
| RPTOR | 0.611 |
| HARS | 0.6 |
| HSPD1 | 0.595 |
| GMPPB | 0.593 |
| MEAF6 | 0.585 |
| ENY2 | 0.579 |
| TTI2 | 0.569 |
| MTOR | 0.568 |
| DPAGT1 | 0.561 |
| CCDC101 | 0.546 |
| THG1L | 0.543 |
| UAP1 | 0.542 |
| PMM2 | 0.541 |
| RTCB | 0.538 |
| NXT1 | 0.538 |
| BAP1 | 0.536 |
| NARS | 0.534 |
| APAF1 | 0.534 |
| TRIAP1 | 0.532 |
| GNB1L | 0.529 |
| OTUD5 | 0.527 |
| CASP9 | 0.525 |
| PPP2R3C | 0.523 |
| ALG1 | 0.515 |
| TTI1 | 0.513 |
| NUPL2 | 0.499 |
| ALG2 | 0.497 |
| PAM16 | 0.496 |
| AARS | 0.495 |
| CBFB | 0.495 |
| EIF4E | 0.494 |
| EPRS | 0.492 |
| HCCS | 0.49 |
| NSD1 | 0.489 |
| MARS | 0.489 |
| CCT7 | 0.489 |
| THOC6 | 0.488 |
| ALG5 | 0.487 |
| MLLT1 | 0.487 |
| WDR24 | 0.487 |
| DOHH | 0.485 |
| CYCS | 0.482 |
| POLR3H | 0.481 |
| SEH1L | 0.481 |
| TSEN54 | 0.477 |
| ATP5J | 0.474 |
| TELO2 | 0.474 |
| UBE2K | 0.473 |
| TLE4 | 0.473 |
| GTF3C3 | 0.471 |
| MED16 | 0.471 |
| MAPK14 | 0.469 |
| SPCS2 | 0.467 |
| DIABLO | 0.466 |
| EXOC4 | 0.465 |
| SLC35B1 | 0.462 |
| ALG14 | 0.461 |
| SRP72 | 0.461 |
| UBA3 | 0.459 |
| MED23 | 0.457 |
| PLAA | 0.454 |
| POLR3B | 0.453 |
| NAE1 | 0.452 |
| TSEN34 | 0.452 |
| TRMT5 | 0.452 |
| UXT | 0.448 |
| CARS | 0.448 |
| PISD | 0.443 |
| VRK1 | 0.442 |
| BAK1 | 0.442 |
| FGFR1OP | 0.441 |
| DNAJC3 | 0.44 |
| UHRF1 | 0.439 |
| SRP68 | 0.437 |
| SEC61G | 0.437 |
| GTF3C2 | 0.435 |
| UBR5 | 0.434 |
| DAD1 | 0.434 |
| TRNT1 | 0.433 |
| CEP350 | 0.433 |
| YARS | 0.432 |
| ENO1 | 0.432 |
| TBCA | 0.432 |
| TAMM41 | 0.43 |
| VHL | 0.427 |
| OSGEP | 0.427 |
| TBCD | 0.426 |
| RPN1 | 0.426 |
| ORAOV1 | 0.425 |
| NSMCE2 | 0.423 |
| SRP14 | 0.422 |
| DPF2 | 0.421 |
| RPE | 0.421 |
| ADSL | 0.421 |
| ZNF608 | 0.42 |
| THOC3 | 0.42 |
| SMARCD1 | 0.419 |
| FBXO11 | 0.417 |
| VMP1 | 0.417 |
| HHEX | 0.417 |
| RPP21 | 0.416 |
| PPA2 | 0.416 |
| TRIP12 | 0.415 |
| TGS1 | 0.415 |
| MARCH5 | 0.413 |
| CTDNEP1 | 0.413 |
| NUP50 | 0.413 |
| ATXN10 | 0.412 |
| CRLS1 | 0.412 |
| NSMCE1 | 0.407 |
| WARS | 0.407 |
| PELO | 0.405 |
| HMGB2 | 0.405 |
| MED4 | 0.404 |
| WDR59 | 0.402 |
| TBP | 0.401 |
| SPCS3 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 655/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 20/28 |
| bone | 22/25 |
| breast | 32/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 12/15 |
| kidney | 16/21 |
| liver | 17/20 |
| lung | 68/75 |
| lymphocyte | 13/14 |
| ovary | 25/26 |
| pancreas | 23/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 21/24 |
| soft tissue | 6/7 |
| thyroid | 1/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 25/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 266
- Expression level (log2 read counts): 6.74
Expression Distribution
CSNK2B Expression in NALM6 Cells: 6.74
