CSPG5 [The Human Chemical-Genetic Interaction Map Project]

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======= CSPG5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSPG5
  * **<color #00a2e8>Official Name</color>**: chondroitin sulfate proteoglycan 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10675|10675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95196|O95196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSPG5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSPG5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neural ProG Cyt|
|Chon Sulph att|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial cell projection elongation|
|trans-synaptic signaling, modulating synaptic transmission|
|dermatan sulfate biosynthetic process|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|dermatan sulfate proteoglycan biosynthetic process|
|dermatan sulfate proteoglycan metabolic process|
|Golgi-associated vesicle membrane|
|chondroitin sulfate biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|positive regulation of substrate adhesion-dependent cell spreading|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|integral component of postsynaptic membrane|
|regulation of substrate adhesion-dependent cell spreading|
|sulfur compound catabolic process|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|GABA-ergic synapse|
|proteoglycan biosynthetic process|
|regulation of synaptic vesicle exocytosis|
|proteoglycan metabolic process|
|lysosomal lumen|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|regulation of neurotransmitter secretion|
|glial cell development|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|regulation of synaptic vesicle cycle|
|positive regulation of cell-substrate adhesion|
|regulation of neurotransmitter transport|
|positive regulation of cell morphogenesis involved in differentiation|
|glycosaminoglycan metabolic process|
|regulation of regulated secretory pathway|
|growth factor activity|
|aminoglycan metabolic process|
|glial cell differentiation|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate derivative catabolic process|
|regulation of cell-substrate adhesion|
|gliogenesis|
|regulation of exocytosis|
|carboxylic acid biosynthetic process|
|regulation of cell morphogenesis involved in differentiation|
|organic acid biosynthetic process|
|glycoprotein biosynthetic process|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|positive regulation of cell adhesion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|drug metabolic process|
|cell part morphogenesis|
|monocarboxylic acid metabolic process|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|small molecule biosynthetic process|
|cell surface|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|regulation of growth|
|regulation of cell adhesion|
|cell morphogenesis|
|regulation of secretion by cell|
|regulation of secretion|
|cellular component morphogenesis|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|regulation of cell development|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cytoskeleton organization|
|cell-cell signaling|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|neurogenesis|
|cell development|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.79|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.81|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.86|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSPG5 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>