CSPG5

Gene Information

Official Symbol: CSPG5
Official Name: chondroitin sulfate proteoglycan 5
Aliases and Previous Symbols: N/A
Entrez ID: 10675
UniProt: O95196
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
UniProt Summary: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.2μM R03 exp108	1.79
S-trityl-L-cysteine 0.5μM R05 exp243	1.81
Etoposide 0.3μM R05 exp199	1.86
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8220
Expression level (log2 read counts): -0.71

Expression Distribution

Neural ProG Cyt
Chon Sulph att

glial cell projection elongation
trans-synaptic signaling, modulating synaptic transmission
dermatan sulfate biosynthetic process
dermatan sulfate metabolic process
chondroitin sulfate catabolic process
dermatan sulfate proteoglycan biosynthetic process
dermatan sulfate proteoglycan metabolic process
Golgi-associated vesicle membrane
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
positive regulation of substrate adhesion-dependent cell spreading
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
integral component of postsynaptic membrane
regulation of substrate adhesion-dependent cell spreading
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
GABA-ergic synapse
proteoglycan biosynthetic process
regulation of synaptic vesicle exocytosis
proteoglycan metabolic process
lysosomal lumen
Golgi lumen
glycosaminoglycan biosynthetic process
regulation of neurotransmitter secretion
glial cell development
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
regulation of synaptic vesicle cycle
positive regulation of cell-substrate adhesion
regulation of neurotransmitter transport
positive regulation of cell morphogenesis involved in differentiation
glycosaminoglycan metabolic process
regulation of regulated secretory pathway
growth factor activity
aminoglycan metabolic process
glial cell differentiation
sulfur compound biosynthetic process
monocarboxylic acid biosynthetic process