CSRNP1

Entrez Summary: This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
UniProt Summary: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. {ECO:0000250, ECO:0000269|PubMed:11526492}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
MED13	0.42
MED13L	0.415

face morphogenesis
platelet-derived growth factor receptor signaling pathway
head morphogenesis
body morphogenesis
face development
post-embryonic development
roof of mouth development
skeletal system morphogenesis
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
transmembrane receptor protein tyrosine kinase signaling pathway
DNA-binding transcription factor activity
enzyme linked receptor protein signaling pathway
molecular function
head development
apoptotic process
animal organ morphogenesis
programmed cell death
cell death
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process