CST11

Entrez Summary: N/A
UniProt Summary: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. {ECO:0000269|PubMed:12072414}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 8μM R07 exp333	1.75
Calcium Ionophore 0.4μM R07 exp342	1.85
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.98
Dorsomorphin 5μM R07 exp357	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm head
cysteine-type endopeptidase inhibitor activity
androgen receptor signaling pathway
sperm flagellum
killing of cells of other organism
disruption of cells of other organism
intracellular steroid hormone receptor signaling pathway
defense response to Gram-negative bacterium
cell killing
steroid hormone mediated signaling pathway
modification of morphology or physiology of other organism
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
negative regulation of endopeptidase activity
negative regulation of peptidase activity
response to steroid hormone
defense response to bacterium
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
response to bacterium
regulation of proteolysis
negative regulation of catalytic activity
interspecies interaction between organisms
response to lipid
response to hormone
response to organic cyclic compound
defense response to other organism
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
cellular response to endogenous stimulus
regulation of hydrolase activity
response to other organism
response to external biotic stimulus