CST7 [The Human Chemical-Genetic Interaction Map Project]

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======= CST7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CST7
  * **<color #00a2e8>Official Name</color>**: cystatin F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8530|8530]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76096|O76096]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CST7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CST7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603253|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cystatin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of microglial cell activation|
|inhibition of cysteine-type endopeptidase activity|
|negative regulation of neuroinflammatory response|
|zymogen inhibition|
|peptidase inhibitor activity|
|negative regulation of macrophage activation|
|regulation of microglial cell activation|
|positive regulation of myelination|
|regulation of neuroinflammatory response|
|multivesicular body|
|negative regulation of protein processing|
|cysteine-type endopeptidase inhibitor activity|
|negative regulation of protein maturation|
|endopeptidase inhibitor activity|
|regulation of myelination|
|regulation of macrophage activation|
|positive regulation of nervous system process|
|regulation of protein processing|
|regulation of protein maturation|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of nervous system process|
|negative regulation of inflammatory response|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|negative regulation of defense response|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|lysosome|
|cytoplasmic vesicle|
|negative regulation of peptidase activity|
|endosome|
|regulation of inflammatory response|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of nervous system development|
|regulation of system process|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of proteolysis|
|regulation of defense response|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|regulation of nervous system development|
|Golgi apparatus|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.09|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.83|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CST7 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>