CST7

Entrez Summary: N/A
UniProt Summary: Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tenofovir 10μM R07 exp405	-2.09
All-trans-Retinoic-Acid 8μM R07 exp333	-1.83
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.73

negative regulation of microglial cell activation
inhibition of cysteine-type endopeptidase activity
negative regulation of neuroinflammatory response
zymogen inhibition
peptidase inhibitor activity
negative regulation of macrophage activation
regulation of microglial cell activation
positive regulation of myelination
regulation of neuroinflammatory response
multivesicular body
negative regulation of protein processing
cysteine-type endopeptidase inhibitor activity
negative regulation of protein maturation
endopeptidase inhibitor activity
regulation of myelination
regulation of macrophage activation
positive regulation of nervous system process
regulation of protein processing
regulation of protein maturation
negative regulation of cysteine-type endopeptidase activity
regulation of nervous system process
negative regulation of inflammatory response
negative regulation of leukocyte activation
negative regulation of cell activation
negative regulation of defense response
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
lysosome
cytoplasmic vesicle
negative regulation of peptidase activity
endosome
regulation of inflammatory response
negative regulation of proteolysis
negative regulation of response to external stimulus
regulation of endopeptidase activity
negative regulation of immune system process
regulation of peptidase activity
negative regulation of hydrolase activity
positive regulation of nervous system development
regulation of system process