CTBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CTBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTBP2
  * **<color #00a2e8>Official Name</color>**: C-terminal binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1488|1488]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56545|P56545]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|2-Hacid dh C|
|2-Hacid dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of presynaptic active zone|
|positive regulation of retinoic acid receptor signaling pathway|
|maintenance of presynaptic active zone structure|
|photoreceptor ribbon synapse|
|presynaptic active zone organization|
|synaptic vesicle docking|
|white fat cell differentiation|
|retinoic acid receptor binding|
|positive regulation of chromatin binding|
|presynaptic active zone cytoplasmic component|
|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|
|presynaptic cytosol|
|maintenance of synapse structure|
|regulation of retinoic acid receptor signaling pathway|
|regulation of chromatin binding|
|viral genome replication|
|NAD binding|
|vesicle docking involved in exocytosis|
|cellular component maintenance|
|transcriptional repressor complex|
|vesicle docking|
|synaptic vesicle exocytosis|
|GABA-ergic synapse|
|exocytic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|signal release from synapse|
|neurotransmitter secretion|
|fat cell differentiation|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|signal release|
|organelle localization by membrane tethering|
|positive regulation of binding|
|membrane docking|
|neurotransmitter transport|
|viral life cycle|
|transcription corepressor activity|
|protein-containing complex binding|
|synapse organization|
|transcription coactivator activity|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|regulation of binding|
|chromatin binding|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|protein kinase binding|
|cell junction|
|organelle localization|
|negative regulation of cell population proliferation|
|viral process|
|regulated exocytosis|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|oxidation-reduction process|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|response to cytokine|
|cell-cell signaling|
|secretion|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.21|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.77|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.473|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTBP2 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>