CTBP2
Gene Information
- Official Symbol: CTBP2
- Official Name: C-terminal binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1488
- UniProt: P56545
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| 2-Hacid dh C |
| 2-Hacid dh |
GO Terms
| structural constituent of presynaptic active zone |
| positive regulation of retinoic acid receptor signaling pathway |
| maintenance of presynaptic active zone structure |
| photoreceptor ribbon synapse |
| presynaptic active zone organization |
| synaptic vesicle docking |
| white fat cell differentiation |
| retinoic acid receptor binding |
| positive regulation of chromatin binding |
| presynaptic active zone cytoplasmic component |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| presynaptic cytosol |
| maintenance of synapse structure |
| regulation of retinoic acid receptor signaling pathway |
| regulation of chromatin binding |
| viral genome replication |
| NAD binding |
| vesicle docking involved in exocytosis |
| cellular component maintenance |
| transcriptional repressor complex |
| vesicle docking |
| synaptic vesicle exocytosis |
| GABA-ergic synapse |
| exocytic process |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| signal release from synapse |
| neurotransmitter secretion |
| fat cell differentiation |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| signal release |
| organelle localization by membrane tethering |
| positive regulation of binding |
| membrane docking |
| neurotransmitter transport |
| viral life cycle |
| transcription corepressor activity |
| protein-containing complex binding |
| synapse organization |
| transcription coactivator activity |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| regulation of binding |
| chromatin binding |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| trans-synaptic signaling |
| synaptic signaling |
| protein kinase binding |
| cell junction |
| organelle localization |
| negative regulation of cell population proliferation |
| viral process |
| regulated exocytosis |
| symbiotic process |
| exocytosis |
| interspecies interaction between organisms |
| oxidation-reduction process |
| secretion by cell |
| cellular response to cytokine stimulus |
| export from cell |
| response to cytokine |
| cell-cell signaling |
| secretion |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinate 1000μM R03 exp140 | -2.21 |
| Lead acetate 2000μM R08 exp498 no dilution day6 | -1.89 |
| Thioridazine 5μM R08 exp530 | 1.77 |
| RS-1 10μM R08 exp519 | 1.78 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.473 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10019
- Expression level (log2 read counts): 6.52
Expression Distribution
CTBP2 Expression in NALM6 Cells: 6.52
