CTDSPL

Entrez Summary: N/A
UniProt Summary: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase II CTD heptapeptide repeat phosphatase activity
phosphoprotein phosphatase activity
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
negative regulation of mitotic cell cycle phase transition
protein dephosphorylation
negative regulation of cell cycle phase transition
negative regulation of mitotic cell cycle
dephosphorylation
negative regulation of cell cycle process
negative regulation of protein phosphorylation
regulation of mitotic cell cycle phase transition
negative regulation of phosphorylation
regulation of cell cycle phase transition
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
regulation of mitotic cell cycle
regulation of cell cycle process
molecular function
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
regulation of cell cycle
regulation of protein phosphorylation
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process