CTGF
Gene Information
- Official Symbol: CCN2
- Official Name: cellular communication network factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1490
- UniProt: P29279
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. {ECO:0000269|PubMed:10614647, ECO:0000269|PubMed:12553878}.
Pfam Domains GO Terms
Pfam Domains
| IGFBP |
| Cys knot |
| VWC |
| TSP 1 |
GO Terms
| response to anoxia |
| positive regulation of G0 to G1 transition |
| extracellular matrix constituent secretion |
| chondrocyte proliferation |
| positive regulation of cardiac muscle contraction |
| positive regulation of striated muscle contraction |
| insulin-like growth factor binding |
| cartilage condensation |
| cell aggregation |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| fibronectin binding |
| response to mineralocorticoid |
| regulation of collagen biosynthetic process |
| positive regulation of heart contraction |
| regulation of collagen metabolic process |
| regulation of G0 to G1 transition |
| positive regulation of muscle contraction |
| regulation of chondrocyte differentiation |
| positive regulation of stress fiber assembly |
| positive regulation of actin filament bundle assembly |
| cis-Golgi network |
| positive regulation of blood circulation |
| regulation of cartilage development |
| regulation of cardiac muscle contraction |
| regulation of stress fiber assembly |
| fibroblast growth factor receptor signaling pathway |
| response to fatty acid |
| cytosolic calcium ion transport |
| regulation of actomyosin structure organization |
| regulation of striated muscle contraction |
| regulation of actin filament bundle assembly |
| integrin-mediated signaling pathway |
| cellular response to fibroblast growth factor stimulus |
| DNA biosynthetic process |
| reactive oxygen species metabolic process |
| response to amino acid |
| response to fibroblast growth factor |
| cell-matrix adhesion |
| integrin binding |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to estradiol |
| cell cortex |
| response to glucose |
| positive regulation of JNK cascade |
| response to hexose |
| response to monosaccharide |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of muscle contraction |
| response to corticosteroid |
| growth factor activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| lung development |
| heparin binding |
| cartilage development |
| response to carbohydrate |
| positive regulation of endopeptidase activity |
| respiratory tube development |
| transcription initiation from RNA polymerase II promoter |
| cell-substrate adhesion |
| regulation of JNK cascade |
| protein C-terminus binding |
| tissue homeostasis |
| positive regulation of peptidase activity |
| respiratory system development |
| positive regulation of supramolecular fiber organization |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| DNA-templated transcription, initiation |
| positive regulation of cytoskeleton organization |
| connective tissue development |
| extracellular matrix |
| regulation of stress-activated MAPK cascade |
| regulation of muscle system process |
| regulation of stress-activated protein kinase signaling cascade |
| skeletal system morphogenesis |
| regulation of cysteine-type endopeptidase activity |
| regulation of heart contraction |
| calcium ion transport |
| regulation of actin filament organization |
| ossification |
| aging |
| positive regulation of cell cycle process |
| regulation of blood circulation |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| divalent inorganic cation transport |
| angiogenesis |
| multicellular organismal homeostasis |
| response to steroid hormone |
| extracellular matrix organization |
| anatomical structure homeostasis |
| regulation of actin cytoskeleton organization |
| response to acid chemical |
| regulation of supramolecular fiber organization |
| positive regulation of proteolysis |
| response to decreased oxygen levels |
| collagen-containing extracellular matrix |
| positive regulation of cell cycle |
| response to oxygen levels |
| extracellular structure organization |
| regulation of actin filament-based process |
| response to peptide hormone |
| blood vessel morphogenesis |
| epidermis development |
| regulation of endopeptidase activity |
| positive regulation of cell activation |
| regulation of peptidase activity |
| response to peptide |
| transcription by RNA polymerase II |
| blood vessel development |
| skeletal system development |
| cellular response to growth factor stimulus |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| regulation of cytoskeleton organization |
| positive regulation of MAPK cascade |
| cell population proliferation |
| response to wounding |
| regulation of system process |
| positive regulation of organelle organization |
| metal ion transport |
| regulation of cell activation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| RNA biosynthetic process |
| tube morphogenesis |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| regulation of cellular response to stress |
| DNA metabolic process |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| cation transport |
| tube development |
| response to lipid |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| response to organonitrogen compound |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| export from cell |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10038
- Expression level (log2 read counts): -4.43
Expression Distribution
CTGF Expression in NALM6 Cells: -4.43
