CTNNA3

Entrez Summary: This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
UniProt Summary: May be involved in formation of stretch-resistant cell- cell adhesion complexes. {ECO:0000303|PubMed:11590244}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cardiac muscle cell-cardiac muscle cell adhesion
fascia adherens
bundle of His cell to Purkinje myocyte communication
regulation of ventricular cardiac muscle cell action potential
regulation of cardiac muscle cell action potential
heterotypic cell-cell adhesion
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
regulation of actin filament-based movement
cell communication involved in cardiac conduction
regulation of action potential
homotypic cell-cell adhesion
regulation of cardiac muscle contraction
beta-catenin binding
regulation of striated muscle contraction
cardiac conduction
regulation of heart rate
multicellular organismal signaling
regulation of muscle contraction
lamellipodium
actin filament binding
regulation of muscle system process
regulation of heart contraction
regulation of blood circulation
cadherin binding
cytoskeleton
regulation of actin filament-based process
regulation of membrane potential
cell-cell adhesion
regulation of system process
cell adhesion
biological adhesion
regulation of cellular component movement