CTNS

Entrez Summary: This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].
UniProt Summary: Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR. {ECO:0000269|PubMed:22649030}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-1.76
Citral 50μM R06 exp274	1.89
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.01
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.5

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of hydrogen peroxide biosynthetic process
L-cystine transport
L-cystine transmembrane transporter activity
sulfur amino acid transport
negative regulation of hydrogen peroxide metabolic process
negative regulation of cofactor metabolic process
regulation of hydrogen peroxide biosynthetic process
positive regulation of mitochondrial membrane potential
melanin biosynthetic process
grooming behavior
melanin metabolic process
positive regulation of membrane potential
secondary metabolite biosynthetic process
regulation of hydrogen peroxide metabolic process
modified amino acid transport
vacuolar membrane
negative regulation of reactive oxygen species biosynthetic process
adult walking behavior
walking behavior
long-term memory
phenol-containing compound biosynthetic process
regulation of cofactor metabolic process
neutral amino acid transport
sulfur compound transport
intermediate filament cytoskeleton
visual learning
pigment biosynthetic process
visual behavior
negative regulation of reactive oxygen species metabolic process
secondary metabolic process
glutathione metabolic process
L-amino acid transport
pigment metabolic process
regulation of mitochondrial membrane potential
adult locomotory behavior
lens development in camera-type eye
associative learning
phenol-containing compound metabolic process
regulation of reactive oxygen species biosynthetic process
melanosome