CTPS1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTPS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTPS1
  * **<color #00a2e8>Official Name</color>**: CTP synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1503|1503]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17812|P17812]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTPS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTPS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CTP synth N|
|Peptidase C26|
|GATase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CTP synthase activity|
|de novo CTP biosynthetic process|
|cytoophidium|
|pyrimidine nucleobase biosynthetic process|
|CTP metabolic process|
|CTP biosynthetic process|
|pyrimidine ribonucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleoside triphosphate metabolic process|
|pyrimidine nucleoside triphosphate biosynthetic process|
|nucleobase biosynthetic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine nucleobase metabolic process|
|glutamine metabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|pyrimidine ribonucleotide metabolic process|
|nucleobase-containing small molecule interconversion|
|T cell proliferation|
|B cell proliferation|
|nucleobase metabolic process|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|glutamine family amino acid metabolic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|nucleoside triphosphate metabolic process|
|leukocyte proliferation|
|pyrimidine-containing compound metabolic process|
|B cell activation|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|alpha-amino acid metabolic process|
|T cell activation|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|cellular amino acid metabolic process|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|lymphocyte activation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.78|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.58|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.56|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.38|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.29|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.15|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.9|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.88|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.85|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.84|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.84|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.84|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.79|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.76|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.97|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.05|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 203/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|19/28|
|bone|0/26|
|breast|12/33|
|central nervous system|5/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|4/21|
|liver|3/20|
|lung|29/75|
|lymphocyte|6/16|
|ovary|3/26|
|pancreas|8/24|
|peripheral nervous system|2/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTPS1 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>