CTPS1

Entrez Summary: This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-2.78
YM155 0.0002μM R01 exp61	-2.58
BI-D1870 2μM R04 exp162	-2.56
Docetaxel 0.002μM R01 exp45	-2.38
Nicotinamide 1000μM R03 exp101	-2.29
Taxol 0.002μM R01 exp54	-2.15
Alpha-Amanitin 0.5μM R00 exp5	-2
Talazoparib 0.006μM R06 exp299	-1.9
Ribavirin 10μM R01 exp52	-1.88
Rifampicin 10μM R00 exp32	-1.85
HMS-I1 1μM R01 exp46	-1.84
IU1-C 25μM R04 exp183	-1.84
Vinblastine 0.002μM R01 exp60	-1.84
2-Methoxyestradiol 0.2μM R01 exp40	-1.79
BI-2536 0.001μM R01 exp41	-1.76
Nocodazole 0.2μM R02 exp64	1.75
Ammonium tetrathiomolybdate 10μM R08 exp448	1.97
Monensin 0.3μM R08 exp507	2.05
GSK591 2.6μM R03 exp128	2.35

Global Fraction of Cell Lines Where Essential: 203/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	11/28
blood	19/28
bone	0/26
breast	12/33
central nervous system	5/56
cervix	1/4
colorectal	5/17
esophagus	5/13
fibroblast	0/1
gastric	4/16
kidney	4/21
liver	3/20
lung	29/75
lymphocyte	6/16
ovary	3/26
pancreas	8/24
peripheral nervous system	2/16
plasma cell	6/15
prostate	1/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	8/29
uterus	0/5

Expression Distribution

CTP synthase activity
de novo CTP biosynthetic process
cytoophidium
pyrimidine nucleobase biosynthetic process
CTP metabolic process
CTP biosynthetic process
pyrimidine ribonucleoside triphosphate biosynthetic process
pyrimidine ribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
nucleobase biosynthetic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleobase metabolic process
glutamine metabolic process
pyrimidine nucleoside triphosphate metabolic process
pyrimidine ribonucleotide metabolic process
nucleobase-containing small molecule interconversion
T cell proliferation
B cell proliferation
nucleobase metabolic process
pyrimidine nucleotide biosynthetic process
ribonucleoside triphosphate biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
glutamine family amino acid metabolic process
lymphocyte proliferation
mononuclear cell proliferation
nucleoside triphosphate metabolic process
leukocyte proliferation
pyrimidine-containing compound metabolic process
B cell activation
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
alpha-amino acid metabolic process
T cell activation
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
cellular amino acid metabolic process
ribonucleotide metabolic process