CTSG [The Human Chemical-Genetic Interaction Map Project]

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======= CTSG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSG
  * **<color #00a2e8>Official Name</color>**: cathepsin G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1511|1511]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08311|P08311]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. {ECO:0000269|PubMed:1861080, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:8194606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neutrophil mediated killing of gram-positive bacterium|
|neutrophil mediated killing of bacterium|
|neutrophil mediated killing of symbiont cell|
|neutrophil mediated cytotoxicity|
|killing by host of symbiont cells|
|disruption by host of symbiont cells|
|angiotensin maturation|
|killing of cells in other organism involved in symbiotic interaction|
|regulation of angiotensin levels in blood|
|disruption of cells of other organism involved in symbiotic interaction|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|defense response to fungus|
|antibacterial humoral response|
|leukocyte mediated cytotoxicity|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|response to fungus|
|disruption of cells of other organism|
|killing of cells of other organism|
|serine-type peptidase activity|
|extracellular matrix disassembly|
|cytoplasmic stress granule|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|peptidase activity|
|defense response to Gram-negative bacterium|
|secretory granule|
|cell killing|
|azurophil granule lumen|
|defense response to Gram-positive bacterium|
|regulation of systemic arterial blood pressure|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|modification of morphology or physiology of other organism|
|protein processing|
|serine-type endopeptidase activity|
|heparin binding|
|regulation of blood pressure|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|hormone metabolic process|
|cellular response to biotic stimulus|
|protein maturation|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|extracellular matrix organization|
|humoral immune response|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|blood circulation|
|circulatory system process|
|cellular component disassembly|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|peptide metabolic process|
|regulation of hormone levels|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|response to bacterium|
|regulated exocytosis|
|leukocyte mediated immunity|
|symbiotic process|
|cellular amide metabolic process|
|exocytosis|
|interspecies interaction between organisms|
|response to lipid|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|protein phosphorylation|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|proteolysis|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to oxygen-containing compound|
|extracellular space|
|regulation of immune system process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3581
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSG Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>