CTSG

Gene Information

Official Symbol: CTSG
Official Name: cathepsin G
Aliases and Previous Symbols: N/A
Entrez ID: 1511
UniProt: P08311
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. {ECO:0000269|PubMed:1861080, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:8194606}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3581
Expression level (log2 read counts): -4.6

Expression Distribution

neutrophil mediated killing of gram-positive bacterium
neutrophil mediated killing of bacterium
neutrophil mediated killing of symbiont cell
neutrophil mediated cytotoxicity
killing by host of symbiont cells
disruption by host of symbiont cells
angiotensin maturation
killing of cells in other organism involved in symbiotic interaction
regulation of angiotensin levels in blood
disruption of cells of other organism involved in symbiotic interaction
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
regulation of systemic arterial blood pressure by renin-angiotensin
peptide hormone processing
regulation of systemic arterial blood pressure by hormone
defense response to fungus
antibacterial humoral response
leukocyte mediated cytotoxicity
regulation of systemic arterial blood pressure mediated by a chemical signal
endocrine process
response to fungus
disruption of cells of other organism
killing of cells of other organism
serine-type peptidase activity
extracellular matrix disassembly
cytoplasmic stress granule
modification by host of symbiont morphology or physiology
interaction with symbiont
peptidase activity
defense response to Gram-negative bacterium
secretory granule
cell killing
azurophil granule lumen
defense response to Gram-positive bacterium
regulation of systemic arterial blood pressure
modification of morphology or physiology of other organism involved in symbiotic interaction
antimicrobial humoral response
modification of morphology or physiology of other organism
protein processing
serine-type endopeptidase activity
heparin binding