CTSK [The Human Chemical-Genetic Interaction Map Project]

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======= CTSK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTSK
  * **<color #00a2e8>Official Name</color>**: cathepsin K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1513|1513]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43235|P43235]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTSK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTSK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601105|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Inhibitor I29|
|Peptidase C1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endolysosome lumen|
|direct ossification|
|intramembranous ossification|
|proteoglycan binding|
|bone resorption|
|fibronectin binding|
|negative regulation of cartilage development|
|cysteine-type peptidase activity|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|regulation of keratinocyte differentiation|
|collagen catabolic process|
|bone remodeling|
|regulation of epidermal cell differentiation|
|collagen binding|
|organelle disassembly|
|collagen metabolic process|
|extracellular matrix disassembly|
|regulation of cartilage development|
|regulation of epidermis development|
|cysteine-type endopeptidase activity|
|lysosomal lumen|
|toll-like receptor signaling pathway|
|tissue remodeling|
|pattern recognition receptor signaling pathway|
|regulation of epithelial cell differentiation|
|tissue homeostasis|
|innate immune response-activating signal transduction|
|lysosome|
|activation of innate immune response|
|autophagy|
|ossification|
|process utilizing autophagic mechanism|
|multicellular organismal homeostasis|
|extracellular matrix organization|
|anatomical structure homeostasis|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|extracellular structure organization|
|cellular component disassembly|
|mitochondrion organization|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|negative regulation of developmental process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|extracellular space|
|homeostatic process|
|regulation of immune system process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.99|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.71|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.71|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.74|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.76|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.82|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.89|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.89|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9358
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTSK Expression in NALM6 Cells: 2.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>