CTSK

Entrez Summary: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013].
UniProt Summary: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Inhibitor I29
Peptidase C1

endolysosome lumen
direct ossification
intramembranous ossification
proteoglycan binding
bone resorption
fibronectin binding
negative regulation of cartilage development
cysteine-type peptidase activity
mitochondrion disassembly
autophagy of mitochondrion
regulation of keratinocyte differentiation
collagen catabolic process
bone remodeling
regulation of epidermal cell differentiation
collagen binding
organelle disassembly
collagen metabolic process
extracellular matrix disassembly
regulation of cartilage development
regulation of epidermis development
cysteine-type endopeptidase activity
lysosomal lumen
toll-like receptor signaling pathway
tissue remodeling
pattern recognition receptor signaling pathway
regulation of epithelial cell differentiation
tissue homeostasis
innate immune response-activating signal transduction
lysosome
activation of innate immune response
autophagy
ossification
process utilizing autophagic mechanism
multicellular organismal homeostasis
extracellular matrix organization
anatomical structure homeostasis
positive regulation of innate immune response
positive regulation of response to biotic stimulus
extracellular structure organization
cellular component disassembly