CTU1 [The Human Chemical-Genetic Interaction Map Project]

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======= CTU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTU1
  * **<color #00a2e8>Official Name</color>**: cytosolic thiouridylase subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90353|90353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z7A3|Q7Z7A3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03053, ECO:0000269|PubMed:19017811}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP bind 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic tRNA wobble base thiouridylase complex|
|protein urmylation|
|tRNA wobble position uridine thiolation|
|tRNA thio-modification|
|nucleotidyltransferase activity|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA binding|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|protein modification by small protein conjugation|
|RNA processing|
|protein modification by small protein conjugation or removal|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.4|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.16|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.85|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.8|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.73|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.7|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.76|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.8|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.84|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.85|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.93|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.93|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.01|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.09|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.12|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.23|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.33|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.35|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.58|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.69|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.76|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:urm1|URM1]]|0.774|
|[[:human genes:m:mocs3|MOCS3]]|0.76|
|[[:human genes:k:kti12|KTI12]]|0.733|
|[[:human genes:e:elp6|ELP6]]|0.722|
|[[:human genes:e:elp2|ELP2]]|0.708|
|[[:human genes:c:ctu2|CTU2]]|0.705|
|[[:human genes:e:elp3|ELP3]]|0.693|
|[[:human genes:d:dph3|DPH3]]|0.686|
|[[:human genes:e:elp4|ELP4]]|0.635|
|[[:human genes:e:elp5|ELP5]]|0.559|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.55|
|[[:human genes:i:ikbkap|IKBKAP]]|0.52|
|[[:human genes:d:dph1|DPH1]]|0.482|
|[[:human genes:t:tsen54|TSEN54]]|0.475|
|[[:human genes:a:alkbh8|ALKBH8]]|0.467|
|[[:human genes:t:thg1l|THG1L]]|0.463|
|[[:human genes:a:asun|ASUN]]|0.455|
|[[:human genes:s:slc7a1|SLC7A1]]|0.449|
|[[:human genes:f:fam98b|FAM98B]]|0.443|
|[[:human genes:a:atic|ATIC]]|0.443|
|[[:human genes:r:rpp21|RPP21]]|0.439|
|[[:human genes:d:dph5|DPH5]]|0.437|
|[[:human genes:m:msto1|MSTO1]]|0.434|
|[[:human genes:s:sbds|SBDS]]|0.431|
|[[:human genes:p:pgm3|PGM3]]|0.431|
|[[:human genes:c:c7orf26|C7orf26]]|0.43|
|[[:human genes:d:dhrsx|DHRSX]]|0.423|
|[[:human genes:k:kdsr|KDSR]]|0.422|
|[[:human genes:s:ssb|SSB]]|0.414|
|[[:human genes:t:tkt|TKT]]|0.412|
|[[:human genes:i:ints10|INTS10]]|0.407|
|[[:human genes:d:dnlz|DNLZ]]|0.407|
|[[:human genes:p:pdap1|PDAP1]]|0.406|
|[[:human genes:d:ddx1|DDX1]]|0.404|
|[[:human genes:a:asb3|ASB3]]|0.404|
|[[:human genes:c:cd2bp2|CD2BP2]]|0.403|
|[[:human genes:k:kdm8|KDM8]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTU1 Expression in NALM6 Cells: 2.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>