CWC22 [The Human Chemical-Genetic Interaction Map Project]

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======= CWC22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CWC22
  * **<color #00a2e8>Official Name</color>**: CWC22 spliceosome associated protein homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57703|57703]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCG8|Q9HCG8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CWC22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CWC22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF4G|
|MA3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type catalytic step 1 spliceosome|
|U2-type catalytic step 2 spliceosome|
|U2-type precatalytic spliceosome|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.85|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.78|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.89|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.98|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.99|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ckap5|CKAP5]]|0.506|
|[[:human genes:c:c14orf93|C14orf93]]|0.505|
|[[:human genes:v:vasn|VASN]]|0.493|
|[[:human genes:h:hap1|HAP1]]|0.485|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:s:snrpa1|SNRPA1]]|0.477|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.473|
|[[:human genes:d:dnm2|DNM2]]|0.47|
|[[:human genes:c:ccdc94|CCDC94]]|0.47|
|[[:human genes:p:psmd1|PSMD1]]|0.469|
|[[:human genes:c:cdc6|CDC6]]|0.466|
|[[:human genes:p:psmb4|PSMB4]]|0.462|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.461|
|[[:human genes:s:sf3a1|SF3A1]]|0.454|
|[[:human genes:t:tfip11|TFIP11]]|0.453|
|[[:human genes:s:snrnp200|SNRNP200]]|0.452|
|[[:human genes:c:cdc73|CDC73]]|0.451|
|[[:human genes:r:rps5|RPS5]]|0.45|
|[[:human genes:r:rps12|RPS12]]|0.449|
|[[:human genes:p:pola2|POLA2]]|0.444|
|[[:human genes:s:stil|STIL]]|0.443|
|[[:human genes:n:nufip2|NUFIP2]]|0.442|
|[[:human genes:s:supt6h|SUPT6H]]|0.442|
|[[:human genes:r:rad21|RAD21]]|0.442|
|[[:human genes:c:chd4|CHD4]]|0.438|
|[[:human genes:p:psmd3|PSMD3]]|0.438|
|[[:human genes:p:psap|PSAP]]|0.438|
|[[:human genes:c:c3|C3]]|0.437|
|[[:human genes:s:srrm2|SRRM2]]|0.437|
|[[:human genes:i:iscu|ISCU]]|0.437|
|[[:human genes:p:psmd6|PSMD6]]|0.436|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.435|
|[[:human genes:p:plrg1|PLRG1]]|0.435|
|[[:human genes:n:nup155|NUP155]]|0.434|
|[[:human genes:o:orc1|ORC1]]|0.433|
|[[:human genes:r:rilpl2|RILPL2]]|0.432|
|[[:human genes:e:eif4a3|EIF4A3]]|0.432|
|[[:human genes:c:chaf1a|CHAF1A]]|0.43|
|[[:human genes:n:ndc1|NDC1]]|0.429|
|[[:human genes:c:cbwd3|CBWD3]]|0.428|
|[[:human genes:n:narfl|NARFL]]|0.428|
|[[:human genes:p:psmd11|PSMD11]]|0.427|
|[[:human genes:p:pola1|POLA1]]|0.426|
|[[:human genes:t:tra2b|TRA2B]]|0.425|
|[[:human genes:s:sec13|SEC13]]|0.423|
|[[:human genes:h:hivep3|HIVEP3]]|0.423|
|[[:human genes:k:kif3c|KIF3C]]|0.422|
|[[:human genes:p:paf1|PAF1]]|0.422|
|[[:human genes:s:ssh2|SSH2]]|0.421|
|[[:human genes:p:prpf8|PRPF8]]|0.42|
|[[:human genes:r:rpsa|RPSA]]|0.42|
|[[:human genes:m:mdm2|MDM2]]|0.418|
|[[:human genes:t:tpx2|TPX2]]|0.418|
|[[:human genes:t:ticrr|TICRR]]|0.418|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.417|
|[[:human genes:c:cox8a|COX8A]]|0.415|
|[[:human genes:c:cbwd6|CBWD6]]|0.415|
|[[:human genes:l:lad1|LAD1]]|0.414|
|[[:human genes:d:dido1|DIDO1]]|0.413|
|[[:human genes:a:ahctf1|AHCTF1]]|0.413|
|[[:human genes:s:supt5h|SUPT5H]]|0.413|
|[[:human genes:t:trim52|TRIM52]]|0.412|
|[[:human genes:n:nupl1|NUPL1]]|0.411|
|[[:human genes:r:rbm39|RBM39]]|0.41|
|[[:human genes:c:cbwd5|CBWD5]]|0.41|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.41|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.41|
|[[:human genes:p:ppie|PPIE]]|0.408|
|[[:human genes:c:copg1|COPG1]]|0.407|
|[[:human genes:r:ranbp2|RANBP2]]|0.406|
|[[:human genes:a:aamp|AAMP]]|0.406|
|[[:human genes:r:rps28|RPS28]]|0.404|
|[[:human genes:r:rrp15|RRP15]]|0.403|
|[[:human genes:p:psmb2|PSMB2]]|0.403|
|[[:human genes:r:rps9|RPS9]]|0.402|
|[[:human genes:d:ddtl|DDTL]]|0.402|
|[[:human genes:n:nup160|NUP160]]|0.402|
|[[:human genes:r:rpl35|RPL35]]|0.402|
|[[:human genes:m:myt1l|MYT1L]]|0.401|
|[[:human genes:p:pan2|PAN2]]|0.4|
|[[:human genes:c:cope|COPE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 709/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|17/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1023
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CWC22 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>