CWC22

Entrez Summary: N/A
UniProt Summary: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 15μM R08 exp443	-1.85
DABN 2μM R00 exp16	1.78
Rifampicin 10μM R00 exp32	1.8
Aminopterin 0.005μM R07 exp335	1.89
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.98
Chloramphenicol 2μM R00 exp12	1.99
Chloramphenicol 20μM R00 exp13	2.52

Global Fraction of Cell Lines Where Essential: 709/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	14/16
kidney	20/21
liver	17/20
lung	71/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	21/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	28/29
uterus	4/5

Expression Distribution

MIF4G
MA3

U2-type catalytic step 1 spliceosome
U2-type catalytic step 2 spliceosome
U2-type precatalytic spliceosome
catalytic step 2 spliceosome
spliceosomal complex
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression