CX3CL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CX3CL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CX3CL1
  * **<color #00a2e8>Official Name</color>**: C-X3-C motif chemokine ligand 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6376|6376]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78423|P78423]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CX3CL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CX3CL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). {ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9931005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcium-independent cell-cell adhesion|
|CXCR1 chemokine receptor binding|
|CX3C chemokine receptor binding|
|negative regulation of hippocampal neuron apoptotic process|
|leukocyte adhesive activation|
|regulation of calcium-independent cell-cell adhesion|
|negative regulation of glutamate receptor signaling pathway|
|negative regulation of interleukin-1 alpha production|
|regulation of hippocampal neuron apoptotic process|
|positive regulation of I-kappaB phosphorylation|
|regulation of interleukin-1 alpha production|
|regulation of I-kappaB phosphorylation|
|microglial cell proliferation|
|negative regulation of microglial cell activation|
|macrophage proliferation|
|autocrine signaling|
|positive regulation of transforming growth factor beta1 production|
|integrin activation|
|negative regulation of tumor necrosis factor secretion|
|synapse pruning|
|regulation of transforming growth factor beta1 production|
|neuron remodeling|
|negative regulation of neuron migration|
|negative regulation of neuroinflammatory response|
|macrophage chemotaxis|
|leukocyte migration involved in inflammatory response|
|angiogenesis involved in wound healing|
|negative regulation of macrophage activation|
|glial cell proliferation|
|regulation of microglial cell activation|
|macrophage migration|
|positive regulation of transforming growth factor beta production|
|eosinophil chemotaxis|
|eosinophil migration|
|positive regulation of neuroblast proliferation|
|regulation of lipopolysaccharide-mediated signaling pathway|
|negative regulation of interleukin-1 beta production|
|regulation of tumor necrosis factor secretion|
|CCR chemokine receptor binding|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|regulation of neuroinflammatory response|
|regulation of neuroblast proliferation|
|negative regulation of interleukin-1 production|
|neuron cellular homeostasis|
|negative regulation of signal transduction in absence of ligand|
|regulation of transforming growth factor beta production|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|chemoattractant activity|
|neuron maturation|
|glial cell activation|
|positive regulation of stem cell proliferation|
|cellular extravasation|
|positive regulation of release of sequestered calcium ion into cytosol|
|neuroinflammatory response|
|regulation of neuron migration|
|negative regulation of interleukin-6 production|
|monocyte chemotaxis|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|lymphocyte chemotaxis|
|mononuclear cell migration|
|positive chemotaxis|
|chemokine activity|
|response to ischemia|
|macrophage activation|
|positive regulation of cell-matrix adhesion|
|positive regulation of neural precursor cell proliferation|
|regulation of macrophage activation|
|positive regulation of calcium ion transport into cytosol|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of actin filament bundle assembly|
|negative regulation of cell-substrate adhesion|
|regulation of glutamate receptor signaling pathway|
|regulation of stem cell proliferation|
|lymphocyte migration|
|negative regulation of cytokine secretion|
|positive regulation of calcium ion transmembrane transport|
|regulation of release of sequestered calcium ion into cytosol|
|chemokine-mediated signaling pathway|
|regulation of interleukin-1 beta production|
|neutrophil chemotaxis|
|positive regulation of smooth muscle cell proliferation|
|regulation of neural precursor cell proliferation|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|regulation of actin filament bundle assembly|
|regulation of interleukin-1 production|
|leukocyte proliferation|
|cell projection|
|regulation of calcium ion transport into cytosol|
|granulocyte migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|myeloid leukocyte migration|
|integrin binding|
|negative regulation of protein secretion|
|regulation of smooth muscle cell proliferation|
|anatomical structure maturation|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|positive regulation of cation transmembrane transport|
|negative regulation of neuron apoptotic process|
|leukocyte chemotaxis|
|regulation of calcium ion transmembrane transport|
|regulation of tumor necrosis factor production|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of ion transmembrane transport|
|cell maturation|
|cellular response to interferon-gamma|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|negative regulation of leukocyte activation|
|cellular response to interleukin-1|
|response to interferon-gamma|
|negative regulation of protein transport|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of establishment of protein localization|
|regulation of synaptic plasticity|
|negative regulation of cell activation|
|positive regulation of supramolecular fiber organization|
|response to interleukin-1|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|negative regulation of defense response|
|cell chemotaxis|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|gliogenesis|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|negative regulation of apoptotic signaling pathway|
|negative regulation of secretion|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|developmental maturation|
|regulation of calcium ion transport|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|regulation of actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|synapse organization|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|positive regulation of ion transport|
|aging|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|angiogenesis|
|neuron projection|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|signaling receptor binding|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|neuronal cell body|
|leukocyte migration|
|positive regulation of cell projection organization|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|wound healing|
|regulation of GTPase activity|
|negative regulation of transport|
|blood vessel development|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|inflammatory response|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cell population proliferation|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|response to wounding|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|tube morphogenesis|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CX3CL1 Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>