CX3CL1
Gene Information
- Official Symbol: CX3CL1
- Official Name: C-X3-C motif chemokine ligand 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6376
- UniProt: P78423
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). {ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9931005}.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| positive regulation of calcium-independent cell-cell adhesion |
| CXCR1 chemokine receptor binding |
| CX3C chemokine receptor binding |
| negative regulation of hippocampal neuron apoptotic process |
| leukocyte adhesive activation |
| regulation of calcium-independent cell-cell adhesion |
| negative regulation of glutamate receptor signaling pathway |
| negative regulation of interleukin-1 alpha production |
| regulation of hippocampal neuron apoptotic process |
| positive regulation of I-kappaB phosphorylation |
| regulation of interleukin-1 alpha production |
| regulation of I-kappaB phosphorylation |
| microglial cell proliferation |
| negative regulation of microglial cell activation |
| macrophage proliferation |
| autocrine signaling |
| positive regulation of transforming growth factor beta1 production |
| integrin activation |
| negative regulation of tumor necrosis factor secretion |
| synapse pruning |
| regulation of transforming growth factor beta1 production |
| neuron remodeling |
| negative regulation of neuron migration |
| negative regulation of neuroinflammatory response |
| macrophage chemotaxis |
| leukocyte migration involved in inflammatory response |
| angiogenesis involved in wound healing |
| negative regulation of macrophage activation |
| glial cell proliferation |
| regulation of microglial cell activation |
| macrophage migration |
| positive regulation of transforming growth factor beta production |
| eosinophil chemotaxis |
| eosinophil migration |
| positive regulation of neuroblast proliferation |
| regulation of lipopolysaccharide-mediated signaling pathway |
| negative regulation of interleukin-1 beta production |
| regulation of tumor necrosis factor secretion |
| CCR chemokine receptor binding |
| leukocyte activation involved in inflammatory response |
| microglial cell activation |
| regulation of neuroinflammatory response |
| regulation of neuroblast proliferation |
| negative regulation of interleukin-1 production |
| neuron cellular homeostasis |
| negative regulation of signal transduction in absence of ligand |
| regulation of transforming growth factor beta production |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| chemoattractant activity |
| neuron maturation |
| glial cell activation |
| positive regulation of stem cell proliferation |
| cellular extravasation |
| positive regulation of release of sequestered calcium ion into cytosol |
| neuroinflammatory response |
| regulation of neuron migration |
| negative regulation of interleukin-6 production |
| monocyte chemotaxis |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| lymphocyte chemotaxis |
| mononuclear cell migration |
| positive chemotaxis |
| chemokine activity |
| response to ischemia |
| macrophage activation |
| positive regulation of cell-matrix adhesion |
| positive regulation of neural precursor cell proliferation |
| regulation of macrophage activation |
| positive regulation of calcium ion transport into cytosol |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of actin filament bundle assembly |
| negative regulation of cell-substrate adhesion |
| regulation of glutamate receptor signaling pathway |
| regulation of stem cell proliferation |
| lymphocyte migration |
| negative regulation of cytokine secretion |
| positive regulation of calcium ion transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| chemokine-mediated signaling pathway |
| regulation of interleukin-1 beta production |
| neutrophil chemotaxis |
| positive regulation of smooth muscle cell proliferation |
| regulation of neural precursor cell proliferation |
| granulocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| neutrophil migration |
| regulation of actin filament bundle assembly |
| regulation of interleukin-1 production |
| leukocyte proliferation |
| cell projection |
| regulation of calcium ion transport into cytosol |
| granulocyte migration |
| negative regulation of extrinsic apoptotic signaling pathway |
| regulation of cell-matrix adhesion |
| positive regulation of cell-substrate adhesion |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| myeloid leukocyte migration |
| integrin binding |
| negative regulation of protein secretion |
| regulation of smooth muscle cell proliferation |
| anatomical structure maturation |
| negative regulation of inflammatory response |
| negative regulation of peptide secretion |
| positive regulation of inflammatory response |
| regulation of interleukin-6 production |
| positive regulation of cation transmembrane transport |
| negative regulation of neuron apoptotic process |
| leukocyte chemotaxis |
| regulation of calcium ion transmembrane transport |
| regulation of tumor necrosis factor production |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of extrinsic apoptotic signaling pathway |
| positive regulation of ion transmembrane transport |
| cell maturation |
| cellular response to interferon-gamma |
| positive regulation of angiogenesis |
| positive regulation of protein kinase B signaling |
| negative regulation of leukocyte activation |
| cellular response to interleukin-1 |
| response to interferon-gamma |
| negative regulation of protein transport |
| positive regulation of vasculature development |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| negative regulation of establishment of protein localization |
| regulation of synaptic plasticity |
| negative regulation of cell activation |
| positive regulation of supramolecular fiber organization |
| response to interleukin-1 |
| positive regulation of transmembrane transport |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| negative regulation of defense response |
| cell chemotaxis |
| regulation of cell-substrate adhesion |
| positive regulation of ERK1 and ERK2 cascade |
| gliogenesis |
| positive regulation of cytoskeleton organization |
| regulation of protein kinase B signaling |
| negative regulation of apoptotic signaling pathway |
| negative regulation of secretion |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to tumor necrosis factor |
| developmental maturation |
| regulation of calcium ion transport |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| regulation of actin filament organization |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| synapse organization |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| positive regulation of ion transport |
| aging |
| positive regulation of neuron projection development |
| positive regulation of cytosolic calcium ion concentration |
| regulation of angiogenesis |
| negative regulation of neurogenesis |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of cellular component movement |
| regulation of neuron death |
| negative regulation of nervous system development |
| angiogenesis |
| neuron projection |
| regulation of vasculature development |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| negative regulation of cell development |
| signaling receptor binding |
| regulation of inflammatory response |
| anatomical structure homeostasis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| neuronal cell body |
| leukocyte migration |
| positive regulation of cell projection organization |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of cell adhesion |
| blood vessel morphogenesis |
| positive regulation of GTPase activity |
| regulation of DNA-binding transcription factor activity |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| wound healing |
| regulation of GTPase activity |
| negative regulation of transport |
| blood vessel development |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| inflammatory response |
| cell-cell adhesion |
| vasculature development |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cell population proliferation |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| response to wounding |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cell surface |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| tube morphogenesis |
| regulation of neuron differentiation |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulation of protein transport |
| cation homeostasis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| defense response to other organism |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9831
- Expression level (log2 read counts): 2.49
Expression Distribution
CX3CL1 Expression in NALM6 Cells: 2.49
