CXCL1

Entrez Summary: N/A
UniProt Summary: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269|PubMed:10095777}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

enzyme activator activity
chemokine activity
tertiary granule lumen
specific granule lumen
antimicrobial humoral immune response mediated by antimicrobial peptide
chemokine-mediated signaling pathway
neutrophil chemotaxis
granulocyte chemotaxis
cellular response to chemokine
response to chemokine
neutrophil migration
granulocyte migration
antimicrobial humoral response
myeloid leukocyte migration
leukocyte chemotaxis
growth factor activity
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cell chemotaxis
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
signaling receptor binding
humoral immune response
leukocyte migration
neutrophil degranulation
neutrophil activation involved in immune response
actin cytoskeleton organization
inflammatory response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
cellular response to lipid
myeloid cell activation involved in immune response
chemotaxis
taxis
actin filament-based process
myeloid leukocyte activation