CXCL11

Gene Information

Official Symbol: CXCL11
Official Name: C-X-C motif chemokine ligand 11
Aliases and Previous Symbols: N/A
Entrez ID: 6373
UniProt: O14625
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17149
Expression level (log2 read counts): -6.6

Expression Distribution

CXCR3 chemokine receptor binding
T cell chemotaxis
T cell migration
positive regulation of release of sequestered calcium ion into cytosol
lymphocyte chemotaxis
chemokine activity
positive regulation of calcium ion transport into cytosol
antimicrobial humoral immune response mediated by antimicrobial peptide
lymphocyte migration
positive regulation of calcium ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
chemokine-mediated signaling pathway
cell
neutrophil chemotaxis
granulocyte chemotaxis
response to chemokine
cellular response to chemokine
neutrophil migration
regulation of calcium ion transport into cytosol
granulocyte migration
antimicrobial humoral response
positive regulation of calcium ion transport
regulation of sequestering of calcium ion
adenylate cyclase-activating G protein-coupled receptor signaling pathway
myeloid leukocyte migration
positive regulation of cation transmembrane transport
leukocyte chemotaxis
cAMP-mediated signaling
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
heparin binding
cyclic-nucleotide-mediated signaling
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
positive regulation of transmembrane transport
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell chemotaxis
cellular response to biotic stimulus
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of calcium ion transport