CXCL16 [The Human Chemical-Genetic Interaction Map Project]

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======= CXCL16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL16
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58191|58191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2A7|Q9H2A7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|low-density lipoprotein particle receptor activity|
|T cell chemotaxis|
|T cell migration|
|lymphocyte chemotaxis|
|chemokine activity|
|scavenger receptor activity|
|lymphocyte migration|
|leukocyte chemotaxis|
|positive regulation of cell growth|
|response to interferon-gamma|
|cell chemotaxis|
|receptor-mediated endocytosis|
|positive regulation of growth|
|response to tumor necrosis factor|
|leukocyte migration|
|regulation of cell growth|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|endocytosis|
|regulation of growth|
|import into cell|
|innate immune response|
|regulation of cell migration|
|regulation of cell motility|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|localization of cell|
|cell motility|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|movement of cell or subcellular component|
|extracellular space|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10854
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL16 Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>