CXCL16

Entrez Summary: N/A
UniProt Summary: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

low-density lipoprotein particle receptor activity
T cell chemotaxis
T cell migration
lymphocyte chemotaxis
chemokine activity
scavenger receptor activity
lymphocyte migration
leukocyte chemotaxis
positive regulation of cell growth
response to interferon-gamma
cell chemotaxis
receptor-mediated endocytosis
positive regulation of growth
response to tumor necrosis factor
leukocyte migration
regulation of cell growth
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
chemotaxis
positive regulation of locomotion
taxis
endocytosis
regulation of growth
import into cell
innate immune response
regulation of cell migration
regulation of cell motility
defense response to other organism
cell migration
regulation of locomotion
regulation of cellular component movement
localization of cell
cell motility
response to cytokine
response to other organism
response to external biotic stimulus
locomotion
G protein-coupled receptor signaling pathway
response to biotic stimulus