CXCL2

Entrez Summary: N/A
UniProt Summary: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269|PubMed:10725737}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chemokine activity
antimicrobial humoral immune response mediated by antimicrobial peptide
chemokine-mediated signaling pathway
neutrophil chemotaxis
granulocyte chemotaxis
cellular response to chemokine
response to chemokine
neutrophil migration
granulocyte migration
antimicrobial humoral response
myeloid leukocyte migration
leukocyte chemotaxis
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cell chemotaxis
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
humoral immune response
leukocyte migration
inflammatory response
cellular response to lipid
chemotaxis
taxis
cytokine-mediated signaling pathway
response to bacterium
response to lipid
cell migration
cellular response to cytokine stimulus
cellular response to oxygen-containing compound
cell motility
localization of cell
response to cytokine
response to other organism
response to external biotic stimulus
locomotion
G protein-coupled receptor signaling pathway
response to biotic stimulus
defense response
movement of cell or subcellular component