CXCR6

Entrez Summary: N/A
UniProt Summary: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

C-X-C chemokine binding
C-X-C chemokine receptor activity
C-C chemokine receptor activity
C-C chemokine binding
chemokine binding
viral genome replication
coreceptor activity
chemokine-mediated signaling pathway
cellular response to chemokine
response to chemokine
calcium-mediated signaling
viral life cycle
cell chemotaxis
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
external side of plasma membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
chemotaxis
taxis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cytokine-mediated signaling pathway
viral process
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
symbiotic process
ion homeostasis
interspecies interaction between organisms
cellular homeostasis
cell migration
cellular response to cytokine stimulus