CXXC4

Entrez Summary: N/A
UniProt Summary: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zygotic specification of dorsal/ventral axis
dorsal/ventral axis specification
embryonic axis specification
embryonic pattern specification
dorsal/ventral pattern formation
axis specification
PDZ domain binding
negative regulation of Wnt signaling pathway
cytoplasmic vesicle
regionalization
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
pattern specification process
zinc ion binding
embryo development
cell-cell signaling
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
DNA binding
negative regulation of response to stimulus