CYB5A

Entrez Summary: The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
UniProt Summary: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-ascorbic acid metabolic process
cytochrome-c oxidase activity
response to cadmium ion
water-soluble vitamin metabolic process
vitamin metabolic process
heme binding
proton transmembrane transport
mitochondrial outer membrane
electron transport chain
monosaccharide metabolic process
coenzyme metabolic process
enzyme binding
response to metal ion
monovalent inorganic cation transport
generation of precursor metabolites and energy
cofactor metabolic process
carbohydrate metabolic process
response to inorganic substance
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
intracellular membrane-bounded organelle
cation transport
carboxylic acid metabolic process
endoplasmic reticulum membrane
ion transmembrane transport
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
transmembrane transport
ion transport
small molecule metabolic process
membrane