CYB5R1

Entrez Summary: N/A
UniProt Summary: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NAD binding 1
FAD binding 6

cytochrome-b5 reductase activity, acting on NAD(P)H
platelet alpha granule membrane
FAD binding
bicarbonate transport
sterol biosynthetic process
steroid biosynthetic process
platelet degranulation
sterol metabolic process
organic hydroxy compound biosynthetic process
steroid metabolic process
organic hydroxy compound metabolic process
organic anion transport
lipid biosynthetic process
anion transport
regulated exocytosis
exocytosis
endoplasmic reticulum membrane
oxidation-reduction process
secretion by cell
export from cell
secretion
lipid metabolic process
mitochondrion
organic cyclic compound biosynthetic process
ion transport
vesicle-mediated transport
membrane