CYP11B1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

corticosterone 18-monooxygenase activity
steroid 11-beta-monooxygenase activity
aldosterone biosynthetic process
tertiary alcohol biosynthetic process
cortisol biosynthetic process
aldosterone metabolic process
cortisol metabolic process
primary alcohol biosynthetic process
mineralocorticoid biosynthetic process
mineralocorticoid metabolic process
aldehyde biosynthetic process
cellular response to potassium ion
glucocorticoid biosynthetic process
tertiary alcohol metabolic process
response to potassium ion
C21-steroid hormone biosynthetic process
glucocorticoid metabolic process
C21-steroid hormone metabolic process
ketone biosynthetic process
steroid hormone biosynthetic process
cellular aldehyde metabolic process
hormone biosynthetic process
cellular ketone metabolic process
primary alcohol metabolic process
alcohol biosynthetic process
cholesterol metabolic process
cellular hormone metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
heme binding
regulation of blood pressure
glucose homeostasis
carbohydrate homeostasis
organic hydroxy compound biosynthetic process
cellular response to metal ion
hormone metabolic process
cellular response to inorganic substance
steroid metabolic process