CYP1A2 [The Human Chemical-Genetic Interaction Map Project]

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======= CYP1A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP1A2
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 1 subfamily A member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1544|1544]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05177|P05177]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP1A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP1A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidative deethylation|
|dibenzo-p-dioxin metabolic process|
|estrogen 2-hydroxylase activity|
|caffeine oxidase activity|
|toxin biosynthetic process|
|monoterpenoid metabolic process|
|demethylase activity|
|alkaloid metabolic process|
|hydrogen peroxide biosynthetic process|
|estrogen 16-alpha-hydroxylase activity|
|omega-hydroxylase P450 pathway|
|antibiotic biosynthetic process|
|secondary metabolite biosynthetic process|
|oxidative demethylation|
|epoxygenase P450 pathway|
|toxin metabolic process|
|reactive oxygen species biosynthetic process|
|response to immobilization stress|
|steroid catabolic process|
|exogenous drug catabolic process|
|cellular response to copper ion|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|long-chain fatty acid biosynthetic process|
|monooxygenase activity|
|estrogen metabolic process|
|porphyrin-containing compound metabolic process|
|cellular response to cadmium ion|
|hydrogen peroxide metabolic process|
|retinol metabolic process|
|response to copper ion|
|secondary metabolic process|
|arachidonic acid metabolic process|
|tetrapyrrole metabolic process|
|demethylation|
|response to cadmium ion|
|electron transfer activity|
|primary alcohol metabolic process|
|post-embryonic development|
|retinoid metabolic process|
|antibiotic metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|long-chain fatty acid metabolic process|
|oxidoreductase activity|
|fatty acid biosynthetic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|xenobiotic metabolic process|
|iron ion binding|
|response to estradiol|
|isoprenoid metabolic process|
|heme binding|
|drug catabolic process|
|fatty acid derivative metabolic process|
|cellular respiration|
|lung development|
|respiratory tube development|
|electron transport chain|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|respiratory system development|
|hormone metabolic process|
|cofactor biosynthetic process|
|cellular response to inorganic substance|
|energy derivation by oxidation of organic compounds|
|steroid metabolic process|
|lipid catabolic process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|methylation|
|response to lipopolysaccharide|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|enzyme binding|
|response to metal ion|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|response to bacterium|
|tube development|
|response to lipid|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.504|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2812
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP1A2 Expression in NALM6 Cells: 2.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>