CYP1A2

Entrez Summary: N/A
UniProt Summary: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269|PubMed:14725854}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

oxidative deethylation
dibenzo-p-dioxin metabolic process
estrogen 2-hydroxylase activity
caffeine oxidase activity
toxin biosynthetic process
monoterpenoid metabolic process
demethylase activity
alkaloid metabolic process
hydrogen peroxide biosynthetic process
estrogen 16-alpha-hydroxylase activity
omega-hydroxylase P450 pathway
antibiotic biosynthetic process
secondary metabolite biosynthetic process
oxidative demethylation
epoxygenase P450 pathway
toxin metabolic process
reactive oxygen species biosynthetic process
response to immobilization stress
steroid catabolic process
exogenous drug catabolic process
cellular response to copper ion
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
long-chain fatty acid biosynthetic process
monooxygenase activity
estrogen metabolic process
porphyrin-containing compound metabolic process
cellular response to cadmium ion
hydrogen peroxide metabolic process
retinol metabolic process
response to copper ion
secondary metabolic process
arachidonic acid metabolic process
tetrapyrrole metabolic process
demethylation
response to cadmium ion
electron transfer activity
primary alcohol metabolic process
post-embryonic development
retinoid metabolic process
antibiotic metabolic process