CYP27A1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity. {ECO:0000250|UniProtKB:P17177}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cholestanetriol 26-monooxygenase activity
cholesterol 26-hydroxylase activity
vitamin D3 25-hydroxylase activity
calcitriol biosynthetic process from calciol
vitamin D biosynthetic process
vitamin D3 metabolic process
cellular alcohol metabolic process
cellular alcohol biosynthetic process
fat-soluble vitamin biosynthetic process
sterol catabolic process
cholesterol catabolic process
vitamin D metabolic process
vitamin biosynthetic process
steroid catabolic process
bile acid biosynthetic process
steroid hydroxylase activity
fat-soluble vitamin metabolic process
bile acid metabolic process
steroid hormone biosynthetic process
alcohol catabolic process
polyol biosynthetic process
hormone biosynthetic process
organic hydroxy compound catabolic process
polyol metabolic process
alcohol biosynthetic process
cholesterol metabolic process
vitamin metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
heme binding
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
hormone metabolic process
steroid metabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process