CYP2J2

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016].
UniProt Summary: This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

arachidonic acid 11,12-epoxygenase activity
arachidonic acid 14,15-epoxygenase activity
linoleic acid epoxygenase activity
isomerase activity
arachidonic acid epoxygenase activity
linoleic acid metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
steroid hydroxylase activity
arachidonic acid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
xenobiotic metabolic process
iron ion binding
heme binding
drug catabolic process
fatty acid derivative metabolic process
cellular response to xenobiotic stimulus
regulation of heart contraction
regulation of blood circulation
response to xenobiotic stimulus
fatty acid metabolic process
drug metabolic process
monocarboxylic acid metabolic process
regulation of system process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
response to drug
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
cellular catabolic process