CYP4F12

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
UniProt Summary: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PU-H71 1μM R08 exp515	-2.16
UM131593 0.1μM R01 exp58	1.76

pressure natriuresis
vitamin E metabolic process
leukotriene B4 catabolic process
leukotriene-B4 20-monooxygenase activity
leukotriene B4 metabolic process
leukotriene catabolic process
alkane 1-monooxygenase activity
icosanoid catabolic process
long-chain fatty acid catabolic process
fatty acid derivative catabolic process
aromatase activity
arachidonic acid epoxygenase activity
renal system process involved in regulation of blood volume
epoxygenase P450 pathway
renal system process involved in regulation of systemic arterial blood pressure
very long-chain fatty acid metabolic process
leukotriene metabolic process
sodium ion homeostasis
renal water homeostasis
fat-soluble vitamin metabolic process
arachidonic acid metabolic process
multicellular organismal water homeostasis
water homeostasis
organic hydroxy compound catabolic process
fatty acid catabolic process
regulation of systemic arterial blood pressure
unsaturated fatty acid metabolic process
renal system process
icosanoid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
vitamin metabolic process
iron ion binding
monovalent inorganic cation homeostasis
heme binding
fatty acid derivative metabolic process
regulation of blood pressure
cellular lipid catabolic process
organic acid catabolic process
carboxylic acid catabolic process