CYP51A1

Entrez Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cholesterol biosynthetic process via 24,25-dihydrolanosterol
sterol 14-demethylase activity
negative regulation of amyloid-beta clearance
regulation of amyloid-beta clearance
cholesterol biosynthetic process
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
demethylation
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
negative regulation of protein secretion
negative regulation of protein catabolic process
iron ion binding
sterol metabolic process
negative regulation of peptide secretion
heme binding
negative regulation of protein transport
negative regulation of establishment of protein localization
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
negative regulation of secretion by cell
negative regulation of secretion
steroid metabolic process
negative regulation of catabolic process
alcohol metabolic process
regulation of protein catabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion