CYR61
Gene Information
- Official Symbol: CCN1
- Official Name: cellular communication network factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3491
- UniProt: O00622
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Pfam Domains GO Terms
Pfam Domains
| IGFBP |
| Cys knot |
| TSP 1 |
| VWC |
GO Terms
| intussusceptive angiogenesis |
| apoptotic process involved in heart morphogenesis |
| chondroblast differentiation |
| chorio-allantoic fusion |
| positive regulation of ceramide biosynthetic process |
| positive regulation of osteoblast proliferation |
| positive regulation of sphingolipid biosynthetic process |
| regulation of sphingolipid biosynthetic process |
| apoptotic process involved in morphogenesis |
| atrial septum morphogenesis |
| regulation of ceramide biosynthetic process |
| regulation of membrane lipid metabolic process |
| labyrinthine layer blood vessel development |
| insulin-like growth factor binding |
| labyrinthine layer morphogenesis |
| atrial septum development |
| regulation of osteoblast proliferation |
| atrioventricular valve morphogenesis |
| epiboly involved in wound healing |
| wound healing, spreading of cells |
| embryonic placenta morphogenesis |
| epiboly |
| atrioventricular valve development |
| apoptotic process involved in development |
| extracellular matrix binding |
| placenta blood vessel development |
| cardiac atrium morphogenesis |
| positive regulation of BMP signaling pathway |
| positive regulation of cartilage development |
| cardiac atrium development |
| positive regulation of bone mineralization |
| labyrinthine layer development |
| positive regulation of biomineral tissue development |
| positive regulation of biomineralization |
| morphogenesis of an epithelial sheet |
| heart valve morphogenesis |
| positive regulation of osteoblast differentiation |
| positive regulation of phospholipase activity |
| heart valve development |
| regulation of cartilage development |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| ventricular septum development |
| cardiac septum morphogenesis |
| regulation of bone mineralization |
| positive regulation of lipid biosynthetic process |
| positive regulation of ossification |
| embryonic placenta development |
| regulation of BMP signaling pathway |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| regulation of lipase activity |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cardiac septum development |
| reactive oxygen species metabolic process |
| regulation of osteoblast differentiation |
| positive regulation of cell-substrate adhesion |
| osteoblast differentiation |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| integrin binding |
| extracellular matrix structural constituent |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of lipid metabolic process |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of cellular amide metabolic process |
| placenta development |
| heparin binding |
| cardiac chamber development |
| cartilage development |
| positive regulation of endopeptidase activity |
| regulation of lipid biosynthetic process |
| regulation of ossification |
| positive regulation of peptidase activity |
| regulation of cell-substrate adhesion |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| connective tissue development |
| extracellular matrix |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cysteine-type endopeptidase activity |
| heart morphogenesis |
| ossification |
| regulation of cellular response to growth factor stimulus |
| regulation of ERK1 and ERK2 cascade |
| endoplasmic reticulum lumen |
| angiogenesis |
| extracellular matrix organization |
| positive regulation of proteolysis |
| post-translational protein modification |
| collagen-containing extracellular matrix |
| in utero embryonic development |
| extracellular structure organization |
| regulation of lipid metabolic process |
| positive regulation of cell adhesion |
| regulation of cellular amide metabolic process |
| blood vessel morphogenesis |
| regulation of endopeptidase activity |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| regulation of peptidase activity |
| wound healing |
| blood vessel development |
| skeletal system development |
| positive regulation of cell migration |
| cell-cell adhesion |
| vasculature development |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| positive regulation of kinase activity |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| regulation of cell adhesion |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| tube development |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| apoptotic process |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| programmed cell death |
| positive regulation of phosphorylation |
| cell motility |
| localization of cell |
| cell death |
| epithelium development |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| locomotion |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12024
- Expression level (log2 read counts): -3.42
Expression Distribution
CYR61 Expression in NALM6 Cells: -3.42
