DAB1 [The Human Chemical-Genetic Interaction Map Project]

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======= DAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAB1
  * **<color #00a2e8>Official Name</color>**: DAB adaptor protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1600|1600]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75553|O75553]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603448|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PID|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration|
|neuronal-glial interaction involved in cerebral cortex radial glia guided migration|
|cerebellum structural organization|
|hindbrain structural organization|
|lateral motor column neuron migration|
|spinal cord motor neuron migration|
|radial glia guided migration of Purkinje cell|
|motor neuron migration|
|hindbrain radial glia guided cell migration|
|negative regulation of astrocyte differentiation|
|midgut development|
|cell migration in hindbrain|
|Golgi localization|
|anatomical structure arrangement|
|negative regulation of receptor signaling pathway via JAK-STAT|
|phosphatidylinositol 3-kinase binding|
|negative regulation of receptor signaling pathway via STAT|
|telencephalon glial cell migration|
|cerebral cortex radial glia guided migration|
|negative regulation of glial cell differentiation|
|regulation of astrocyte differentiation|
|cerebral cortex radially oriented cell migration|
|adult walking behavior|
|walking behavior|
|glial cell migration|
|cerebellum morphogenesis|
|negative regulation of gliogenesis|
|hindbrain morphogenesis|
|cerebral cortex cell migration|
|ventral spinal cord development|
|brush border|
|telencephalon cell migration|
|forebrain cell migration|
|regulation of glial cell differentiation|
|negative regulation of axonogenesis|
|apical part of cell|
|adult locomotory behavior|
|hippocampus development|
|negative regulation of cell morphogenesis involved in differentiation|
|dendrite development|
|cerebellum development|
|spinal cord development|
|limbic system development|
|metencephalon development|
|regulation of gliogenesis|
|cerebral cortex development|
|neuron migration|
|regulation of receptor signaling pathway via JAK-STAT|
|digestive tract development|
|regulation of receptor signaling pathway via STAT|
|digestive system development|
|adult behavior|
|hindbrain development|
|negative regulation of neuron projection development|
|pallium development|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|locomotory behavior|
|gliogenesis|
|negative regulation of neuron differentiation|
|postsynaptic density|
|telencephalon development|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell adhesion|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|neuron projection|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|neuronal cell body|
|axonogenesis|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|behavior|
|positive regulation of kinase activity|
|organelle localization|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of kinase activity|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13806
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAB1 Expression in NALM6 Cells: -1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>