DAB1
Gene Information
- Official Symbol: DAB1
- Official Name: DAB adaptor protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1600
- UniProt: O75553
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PID |
GO Terms
| cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration |
| neuronal-glial interaction involved in cerebral cortex radial glia guided migration |
| cerebellum structural organization |
| hindbrain structural organization |
| lateral motor column neuron migration |
| spinal cord motor neuron migration |
| radial glia guided migration of Purkinje cell |
| motor neuron migration |
| hindbrain radial glia guided cell migration |
| negative regulation of astrocyte differentiation |
| midgut development |
| cell migration in hindbrain |
| Golgi localization |
| anatomical structure arrangement |
| negative regulation of receptor signaling pathway via JAK-STAT |
| phosphatidylinositol 3-kinase binding |
| negative regulation of receptor signaling pathway via STAT |
| telencephalon glial cell migration |
| cerebral cortex radial glia guided migration |
| negative regulation of glial cell differentiation |
| regulation of astrocyte differentiation |
| cerebral cortex radially oriented cell migration |
| adult walking behavior |
| walking behavior |
| glial cell migration |
| cerebellum morphogenesis |
| negative regulation of gliogenesis |
| hindbrain morphogenesis |
| cerebral cortex cell migration |
| ventral spinal cord development |
| brush border |
| telencephalon cell migration |
| forebrain cell migration |
| regulation of glial cell differentiation |
| negative regulation of axonogenesis |
| apical part of cell |
| adult locomotory behavior |
| hippocampus development |
| negative regulation of cell morphogenesis involved in differentiation |
| dendrite development |
| cerebellum development |
| spinal cord development |
| limbic system development |
| metencephalon development |
| regulation of gliogenesis |
| cerebral cortex development |
| neuron migration |
| regulation of receptor signaling pathway via JAK-STAT |
| digestive tract development |
| regulation of receptor signaling pathway via STAT |
| digestive system development |
| adult behavior |
| hindbrain development |
| negative regulation of neuron projection development |
| pallium development |
| negative regulation of cell projection organization |
| regulation of axonogenesis |
| locomotory behavior |
| gliogenesis |
| negative regulation of neuron differentiation |
| postsynaptic density |
| telencephalon development |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| axon guidance |
| neuron projection guidance |
| negative regulation of cell adhesion |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| small GTPase mediated signal transduction |
| neuron projection |
| negative regulation of cell development |
| positive regulation of neuron differentiation |
| neuronal cell body |
| axonogenesis |
| forebrain development |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell-cell adhesion |
| cell part morphogenesis |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| behavior |
| positive regulation of kinase activity |
| organelle localization |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| brain development |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of kinase activity |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bisphenol S 100μM R08 exp458 | -1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13806
- Expression level (log2 read counts): -1.24
Expression Distribution
DAB1 Expression in NALM6 Cells: -1.24
