DACH1

Gene Information

Official Symbol: DACH1
Official Name: dachshund family transcription factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 1602
UniProt: Q9UI36
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6470
Expression level (log2 read counts): -2.38

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	1.74
BI-D1870 2μM R04 exp162	1.76

negative regulation of cell proliferation involved in contact inhibition
contact inhibition
negative regulation of transcription by competitive promoter binding
suckling behavior
regulation of nuclear cell cycle DNA replication
negative regulation of fibroblast proliferation
negative regulation of DNA biosynthetic process
respiratory gaseous exchange by respiratory system
regulation of DNA-dependent DNA replication
multi-organism behavior
regulation of fibroblast proliferation
feeding behavior
development of primary female sexual characteristics
female sex differentiation
regulation of DNA replication
regulation of DNA biosynthetic process
negative regulation of DNA metabolic process
transcription factor complex
development of primary sexual characteristics
DNA-binding transcription repressor activity, RNA polymerase II-specific
negative regulation of cell migration
sex differentiation
negative regulation of cell motility
negative regulation of cellular component movement
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of locomotion
regulation of DNA metabolic process
RNA polymerase II proximal promoter sequence-specific DNA binding
cell population proliferation
behavior
developmental process involved in reproduction
negative regulation of cell population proliferation
regulation of cell cycle process
regulation of cell migration
negative regulation of transcription by RNA polymerase II
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
regulation of cell cycle
negative regulation of transcription, DNA-templated