DACT2

Entrez Summary: N/A
UniProt Summary: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of nodal signaling pathway
inner medullary collecting duct development
delta-catenin binding
regulation of nodal signaling pathway
negative regulation of activin receptor signaling pathway
collecting duct development
protein kinase A binding
regulation of activin receptor signaling pathway
epithelial cell morphogenesis
protein kinase C binding
beta-catenin binding
hematopoietic progenitor cell differentiation
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
epithelial cell development
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
kidney development
negative regulation of cell adhesion
renal system development
urogenital system development
transcription factor binding
regulation of Wnt signaling pathway
skin development
cell morphogenesis involved in differentiation
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
epithelial cell differentiation
regulation of cell adhesion
cell morphogenesis
cellular component morphogenesis
tube development
epithelium development
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
cell development
tissue development