DACT3

Entrez Summary: N/A
UniProt Summary: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

delta-catenin binding
protein kinase A binding
negative regulation of epithelial to mesenchymal transition
protein kinase C binding
beta-catenin binding
regulation of epithelial to mesenchymal transition
negative regulation of canonical Wnt signaling pathway
negative regulation of cell growth
negative regulation of Wnt signaling pathway
negative regulation of growth
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
regulation of cell growth
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of growth
negative regulation of cell differentiation
negative regulation of developmental process
identical protein binding
cell-cell signaling
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
regulation of cell differentiation