DAG1 [The Human Chemical-Genetic Interaction Map Project]

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======= DAG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAG1
  * **<color #00a2e8>Official Name</color>**: dystroglycan 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1605|1605]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14118|Q14118]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/128239|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAG1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dystroglycan complex|
|nerve maturation|
|calcium-dependent cell-matrix adhesion|
|retrograde trans-synaptic signaling by trans-synaptic protein complex|
|regulation of embryonic cell shape|
|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of basement membrane organization|
|laminin-1 binding|
|contractile ring|
|retrograde trans-synaptic signaling|
|trans-synaptic signaling by trans-synaptic complex|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|response to muscle inactivity involved in regulation of muscle adaptation|
|cytoskeletal anchoring at plasma membrane|
|response to denervation involved in regulation of muscle adaptation|
|dystroglycan binding|
|vinculin binding|
|response to muscle inactivity|
|commissural neuron axon guidance|
|nuclear periphery|
|response to inactivity|
|response to stimulus involved in regulation of muscle adaptation|
|angiogenesis involved in wound healing|
|node of Ranvier|
|positive regulation of myelination|
|branching involved in salivary gland morphogenesis|
|dystrophin-associated glycoprotein complex|
|alpha-actinin binding|
|regulation of receptor localization to synapse|
|postsynaptic cytosol|
|cellular response to cholesterol|
|costamere|
|positive regulation of extracellular matrix organization|
|cellular response to sterol|
|basement membrane organization|
|axon regeneration|
|membrane protein ectodomain proteolysis|
|positive regulation of oligodendrocyte differentiation|
|peripheral nervous system axon ensheathment|
|regulation of protein localization to synapse|
|epithelial tube branching involved in lung morphogenesis|
|microtubule anchoring|
|response to cholesterol|
|myelination in peripheral nervous system|
|neuron projection regeneration|
|Schwann cell development|
|salivary gland morphogenesis|
|response to sterol|
|plasma membrane raft|
|modulation by virus of host morphology or physiology|
|salivary gland development|
|Schwann cell differentiation|
|skeletal muscle tissue regeneration|
|SH2 domain binding|
|membrane protein proteolysis|
|regulation of gastrulation|
|positive regulation of embryonic development|
|regulation of extracellular matrix organization|
|regulation of oligodendrocyte differentiation|
|modification by symbiont of host morphology or physiology|
|regulation of myelination|
|positive regulation of glial cell differentiation|
|lung morphogenesis|
|exocrine system development|
|structural constituent of muscle|
|negative regulation of protein kinase B signaling|
|response to axon injury|
|morphogenesis of an epithelial sheet|
|positive regulation of cell-matrix adhesion|
|tubulin binding|
|tissue regeneration|
|positive regulation of nervous system process|
|GABA-ergic synapse|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|filopodium|
|peripheral nervous system development|
|maintenance of protein location in cell|
|virus receptor activity|
|nerve development|
|cellular response to mechanical stimulus|
|regulation of epithelial to mesenchymal transition|
|cellular response to alcohol|
|regulation of muscle adaptation|
|basement membrane|
|viral entry into host cell|
|maintenance of location in cell|
|sarcolemma|
|gland morphogenesis|
|Golgi lumen|
|entry into host|
|entry into host cell|
|cell-cell adherens junction|
|myelination|
|maintenance of protein location|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of protein localization to cell periphery|
|regulation of cell-matrix adhesion|
|regulation of gliogenesis|
|positive regulation of cell-substrate adhesion|
|cell-matrix adhesion|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|anatomical structure maturation|
|regulation of nervous system process|
|regulation of cell shape|
|modification of morphology or physiology of other organism|
|regeneration|
|interaction with host|
|morphogenesis of a branching epithelium|
|maintenance of location|
|negative regulation of MAPK cascade|
|morphogenesis of a branching structure|
|lung development|
|glial cell differentiation|
|respiratory tube development|
|lamellipodium|
|cell-substrate adhesion|
|regulation of protein localization to membrane|
|respiratory system development|
|basolateral plasma membrane|
|postsynaptic membrane|
|viral life cycle|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|gliogenesis|
|regulation of synapse organization|
|regulation of protein kinase B signaling|
|regulation of synapse structure or activity|
|response to alcohol|
|regulation of muscle system process|
|developmental maturation|
|negative regulation of cell migration|
|axon guidance|
|neuron projection guidance|
|actin binding|
|negative regulation of cell motility|
|aging|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|angiogenesis|
|negative regulation of locomotion|
|cellular response to external stimulus|
|extracellular matrix organization|
|glutamatergic synapse|
|collagen-containing extracellular matrix|
|cytoskeleton|
|axonogenesis|
|extracellular structure organization|
|developmental growth|
|response to peptide hormone|
|growth|
|external side of plasma membrane|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|gland development|
|focal adhesion|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|negative regulation of phosphorylation|
|synaptic signaling|
|positive regulation of neurogenesis|
|response to peptide|
|microtubule cytoskeleton organization|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|microtubule-based process|
|regulation of cell adhesion|
|viral process|
|calcium ion binding|
|cell morphogenesis|
|regulation of MAPK cascade|
|symbiotic process|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16558
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAG1 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>