DAG1

Gene Information

Official Symbol: DAG1
Official Name: dystroglycan 1
Aliases and Previous Symbols: N/A
Entrez ID: 1605
UniProt: Q14118
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015].
UniProt Summary: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16558
Expression level (log2 read counts): 5.42

Expression Distribution

dystroglycan complex
nerve maturation
calcium-dependent cell-matrix adhesion
retrograde trans-synaptic signaling by trans-synaptic protein complex
regulation of embryonic cell shape
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
regulation of basement membrane assembly involved in embryonic body morphogenesis
regulation of basement membrane organization
laminin-1 binding
contractile ring
retrograde trans-synaptic signaling
trans-synaptic signaling by trans-synaptic complex
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
response to muscle inactivity involved in regulation of muscle adaptation
cytoskeletal anchoring at plasma membrane
response to denervation involved in regulation of muscle adaptation
dystroglycan binding
vinculin binding
response to muscle inactivity
commissural neuron axon guidance
nuclear periphery
response to inactivity
response to stimulus involved in regulation of muscle adaptation
angiogenesis involved in wound healing
node of Ranvier
positive regulation of myelination
branching involved in salivary gland morphogenesis
dystrophin-associated glycoprotein complex
alpha-actinin binding
regulation of receptor localization to synapse
postsynaptic cytosol
cellular response to cholesterol
costamere
positive regulation of extracellular matrix organization
cellular response to sterol
basement membrane organization
axon regeneration
membrane protein ectodomain proteolysis
positive regulation of oligodendrocyte differentiation
peripheral nervous system axon ensheathment