DAO

Entrez Summary: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. {ECO:0000269|PubMed:17303072}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
QNZ 0.01μM R08 exp439	-1.89
Citral 75μM R06 exp275	2.51

D-alanine catabolic process
D-serine catabolic process
D-alanine family amino acid metabolic process
D-alanine metabolic process
D-amino-acid oxidase activity
D-serine metabolic process
D-amino acid catabolic process
D-amino acid metabolic process
proline catabolic process
alanine metabolic process
alanine catabolic process
pyruvate family amino acid metabolic process
pyruvate family amino acid catabolic process
dopamine biosynthetic process
proline metabolic process
serine family amino acid catabolic process
cofactor binding
catechol-containing compound biosynthetic process
catecholamine biosynthetic process
glutamine family amino acid catabolic process
dopamine metabolic process
FAD binding
phenol-containing compound biosynthetic process
serine family amino acid metabolic process
catechol-containing compound metabolic process
catecholamine metabolic process
peroxisomal matrix
peroxisomal membrane
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
glutamine family amino acid metabolic process
peroxisome organization
phenol-containing compound metabolic process
alpha-amino acid catabolic process
peroxisome
cellular amino acid catabolic process
drug catabolic process
protein dimerization activity