DARS [The Human Chemical-Genetic Interaction Map Project]

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======= DARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DARS1
  * **<color #00a2e8>Official Name</color>**: aspartyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1615|1615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14868|P14868]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603084|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA anti|
|tRNA-synt 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aspartyl-tRNA aminoacylation|
|aspartate-tRNA ligase activity|
|aminoacylase activity|
|aminoacyl-tRNA synthetase multienzyme complex|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|synapse|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.71|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.71|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.74|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.75|
|[[:results:exp303|39°C R06 exp303]]|1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.81|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.08|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.17|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.17|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.641|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 602/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|26/28|
|bone|21/26|
|breast|27/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|16/21|
|liver|15/20|
|lung|66/75|
|lymphocyte|13/16|
|ovary|20/26|
|pancreas|20/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|22/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 809
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DARS Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>